Sulfated Cholecystokinin-8 Promotes CD36—Mediated Fatty Acid Uptake into Primary Mouse Duodenal Enterocytes

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Sulfated Cholecystokinin-8 Promotes CD36—Mediated Fatty Acid Uptake into Primary Mouse Duodenal Enterocytes

Cholecystokinin (CCK) is an archetypal incretin hormone secreted by intestinal enteroendocrine cells (EEC) in response to ingested nutrients. The aim of this study was to determine whether CCK modulates enterocyte fatty acid uptake by primary mouse duodenal cells. Exposure of primary mouse duodenal cells to 10 pM sulfated CCK-8 caused a two fold increase in dodecanoic acid fatty acid (FA) uptak...

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ژورنال

عنوان ژورنال: Frontiers in Physiology

سال: 2017

ISSN: 1664-042X

DOI: 10.3389/fphys.2017.00660